02.10.2009Quantification of oxidative stress
The new product "oxidized DNA ELISA" (EK-ODG) is available now. The assay allows the quantitative detection of oxidized guanosin (8-OHdG) in urine which is one of the major products of oxidative Stress in the individual’s body. The ELISA is a complete and user-friendly kit.
Normal metabolism of oxygen produces so-called Reactive Oxygen Species (ROS) which are highly reactive molecules. ROS permanently damage lipids of cellular membranes, proteins and also DNA and RNA.
In healthy people there is a balance between oxidants (ROS) and anti-oxidants and highly effective repair mechanisms which prevent continual destruction of genetic material.
In research oxidative stress takes a prominent place in the prevention of very different diseases. Numerous studies show tight correlation between oxidative stress and the appearance of more than 200 diseases like arthrosclerosis, AIDS, inflammatory diseases, Diabetes mellitus and general aging as well as cancer.
The knowledge of the individual oxidative stress status can be regarded as disease prevention.
Today, numerous service laboratories in the western countries offer already a large panel of different tests to estimate the status of oxidative stress. Besides the determination of anti-oxidants, micronutrients and marker of the iron metabolism oxidized lipids and DNA are of major interest.
Determination of oxidized DNA therefore must be regarded as one important brick in a complete clarification of the individual’s health and aging status.